Project: ENCODE

The National Human Genome Research Institute (NHGRI) launched a public research consortium named ENCODE, the Encyclopedia Of DNA Elements, in September 2003, to carry out a project to identify all functional elements in the human genome sequence. The project started with two components - a pilot phase and a technology development phase. The pilot phase tested and compared existing methods to rigorously analyze a defined portion of the human genome sequence (See: ENCODE Pilot Project). The conclusions from this pilot project were published in June 2007 in Nature PDF icon and Genome Research []. The findings highlighted the success of the project to identify and characterize functional elements in the human genome. The technology development phase also has been a success with the promotion of several new technologies to generate high throughput data on functional elements.Within the ENCODE consortium, the goals of the ENCODE Transcriptome group are to generate maps of human RNAs, a dynamic population. In order to capture part of the vast diversity of transcripts we are targeting distinct populations based on size, structure, cellular compartment and associated ribonucleoproteins and classifying them according to their above properties in ENCODE cell lines. Part of this job is done using the information from the sequencing of the transcriptome using the Next Generation sequencing tecnologies (RNAseq), and these data are the ones presented here. More information on the ENCODE project can be obtained at:


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